Author

Elim Choi

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Agnel J. SfeiriD· 2 shared Craig B. ThompsoniD· 2 shared Ruobing CuiiD· 2 shared Tamar KavlashviliiD· 2 shared Caleb A. LareauiD· 1 shared Dana Pe’eriD· 1 shared Daphne Baker· 1 shared Ed ReznikiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Agnel J. SfeirORCID

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2 papers

Recent·Most cited

MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulation

Tamar Kavlashvili, Elim Choi, Ruobing Cui, Juan C. Landoni, Simon Zhang, R. Stefan Isaac, L. Stirling Churchman, Suliana Manley, Craig B. Thompson, Agnel J. Sfeir

The paper identifies MTERF1 as a suppressor of mtDNA deletion pathologies by showing its loss enhances mitochondrial function through transcriptional relief.

bioRxiv · Jul 17, 2026 · PreprintMolecular Biology

Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria

Yi Fu, Max Land, Tamar Kavlashvili, Ruobing Cui, Min‐Soo Kim, Emily DeBitetto, Toby Lieber, Keun Woo Ryu, Elim Choi, Ignas Masilionis, Rahul Saha, Meril T. Takizawa, Daphne Baker, Marco Tigano, Caleb A. Lareau, , Agnel J. Sfeir

This paper develops a method to engineer specific mtDNA deletions in human cells using end-joining machinery and targeted endonucleases, revealing a 75% heteroplasmy threshold for mitochondrial dysfunction.

Cell · May 1, 2025Peer-reviewedMolecular Biology