Intracellular accumulation of AAV6 genomes governs microglia reactivity and the inflammatory response in retinal gene therapy
Allwyn Pereira, Jean-Baptiste Ducloyer, Joanna Demilly, Estelle Toublanc, Lyse Libeau, Bérangère Robert, Anthony Mellet, David Augereau, Léa Comtesse, Thibaut Larcher, Alix Lebreton, Paul Socheleau, Marion G�rard, Malo Journou, Celia Couzinié, , Thérèse Cronin
This study shows that intracellular accumulation of AAV6 genomes in microglia drives reactivity and inflammation in retinal gene therapy.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience