Microglial AhR Drives Sex-Biased Amyloid Pathology
Carmen Nieto-Vaquero, Alicia Garcia-Culebras, Andrea Rubio-Ponce, David Chamoso-Sanchez, Manuel J. Gomez, F. Javier de Castro-Millan, Carlos Parra-Perez, Sandra Vazquez-Reyes, Aurora Semerano, Isabel Bravo-Ferrer, Ana Moraga-Yebenes, Coral Barbas, Hector Bueno, Estrella Morenas-Rodriguez, Fatima Sanchez-Cabo, , Maria Angeles Moro
This study identifies microglial AhR as a regulator of sex-biased amyloid pathology, showing that AhR activation exacerbates amyloid deposition and that AhR deficiency reduces amyloid burden.
bioRxiv · Nov 6, 2026 · PreprintImmunology