Author

David DeNardo

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Carlos CruchagaiD· 1 shared Di HuangiD· 1 shared Douglas Faget· 1 shared Edward CamposiD· 1 shared Fuhai LiiD· 1 shared Ganesh Raut· 1 shared Guangfu LiiD· 1 shared Hao LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Carlos CruchagaORCID

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Author profile →

2 papers

Recent·Most cited

Targeting MK2-Driven Stromal Senescence Sensitizes Breast Cancer Bone Metastasis to Immunotherapy

Renata Ferreira, Douglas Faget, Radhika Mishra, Ganesh Raut, Edward Campos, Xianmin Luo, Yu Tao, Jingqin Luo, David DeNardo, Sheila A. Stewart

This study identifies senescent cancer-associated fibroblasts (senCAFs) driven by MK2 that promote immunosuppression in bone metastases and shows that combining MK2 inhibition with OX40 agonists enhances immunotherapy efficacy.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

OmniCellAgent: An AI Scientist for Omic-Driven Scientific Discovery

Di Huang, Hao Li, Wenyu Li, Heming Zhang, Tianqi Xu, Yifei Lu, Kaiwen Fang, Zixi Xu, Justin Chen, Patricia Dickson, Marco Sardiello, William Buchser, Jonathan D. Cooper, Carlos Cruchaga, Pirooz Eghtesady, , Fuhai Li

OmniCellAgent autonomously retrieves and analyzes scRNA-seq datasets to generate structured reports and hypotheses across disease settings.

bioRxiv · Jul 31, 2025 · PreprintBioinformatics