Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi, Kuldeep Kumar Tripathi, Yong Huang, Akiko Asada, Linda Söderberg, Erin Bresnahan, David Lerner, Francesca Garretti, Hong Zhang, Jonathan van de Loo, Cheryl D. Stimpson, Ronan Talty, Charles Glabe, , Michelle E. Ehrlich
This study shows that nonfibrillar Aβ aggregates in APPE693Q mice disrupt presynaptic function without causing inflammation.
Alzheimer s & Dementia · Jun 1, 2026Peer-reviewedNeuroscience