miR-34/449 miRNAs regulate choroid plexus ciliogenesis to control cerebrospinal fluid production
Suifang Mao, Rui Song, Aleksandra Jovanović, Shibo Jin, Song Pang, Danielle M. Jorgens, Michael F. Wendland, Adam Zimmerman, David Lin, Zhenyu Xuan, C. Shan Xu, Harald F. Hess, Srigokul Upadhyayula, Lin He
This study identifies miR-34/449 miRNAs as regulators of choroid plexus multiciliogenesis, showing their role in controlling cerebrospinal fluid production through modulation of Shh signaling.
bioRxiv · Sep 1, 2026 · PreprintDevelopmental Biology