TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate
Michelle Y. Meng, Luke W Paine, David Sagnat, Ivana Bello, Sophie Oldroyd, Farideh A. Javid, Matthew Thomas Harper, James R.F. Hockley, Ewan St. John Smith, Róisín M. Owens, Laurent Alric, Étienne Buscail, Fraser Welsh, Nathalie Vergnolle, David Colin Bulmer
This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.
British Journal of Pharmacology · Dec 3, 2024Peer-reviewedPharmacology & Toxicology