David Smith

Phenotypic screening in Parkinson's iPSC-dopamine neurons identifies the FASN-SREBP1 axis as a potential therapeutic target

The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.

Limits of marker information transfer]{Limits of marker information transfer in cross-panel cytometry imputation

This study evaluates the limits of marker information transfer in cross-panel cytometry imputation, finding that imputation preserves broad lineage classification but not fine-phenotype details, and that patient matching improves cross-platform distribution recovery.

Damaged glomeruli in proliferative pediatric lupus nephritis exhibit a C5a-C5aR1 induced fibrotic transcriptional program

The paper identifies a C5a-C5aR1 signaling pathway driving fibrosis in damaged glomeruli of pediatric lupus nephritis using spatial transcriptomics and bulk RNA-seq.

Ready-to-use nanopore platform for ethanolamine quantification using an aptamer-based strand displacement assay.

The paper describes a method to quantify ethanolamine using a nanopore-based strand displacement assay with an ethanolamine-specific aptamer.

The Northern Arizona SNP Pipeline (NASP): accurate, flexible, and rapid identification of SNPs in WGS datasets

NASP is a WGS pipeline for SNP detection in bacterial genomes, showing comparable or better performance than existing tools with greater flexibility.