Phenotypic screening in Parkinson's iPSC-dopamine neurons identifies the FASN-SREBP1 axis as a potential therapeutic target
Maria Claudia Caiazza, Janine Brandes, Elizabeth R. Barrow, Ricardo Márquez-Gómez, Dean G. Brown, Benjamin Jenkins, Uroosa Chughtai, William McGuinness, Stewart W. Humble, Parnaz Sharifi, Johanna L. Hoffmann, Matthieu Trigano, Albert Koulman, Ian Gurrell, Andrew Davis, , Richard Wade‐Martins
The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.
bioRxiv · Nov 1, 2026 · PreprintNeuroscience