Orthogonal and Robust Analytics Enable Reproducible and Scalable Manufacturing of High Purity Extracellular Vesicles Derived from Mesenchymal Stromal Cells
Mehdi Dehghani, Meng Chai, Nazanin Talebloo, Molly Morrissey, Andrew M. Larey, Yuriy Kim, Camille V. Trinidad, Deepika Joshi, Yuxuan Wu, Yichen Zhong, Ran Cheng, Yisheng Lu, Behnaz Lahooti, Mohammad Naimul Islam, Zheng Zhao, , Ethan Kishimori
This paper develops an analytical toolbox and scalable downstream processing workflow for high purity extracellular vesicles from mesenchymal stromal cells, using orthogonal methods to improve reproducibility and purity.
bioRxiv · Aug 26, 2025 · PreprintBioengineering