Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling
Aleksandra Judina, Zhiyao Shi, Jiarong Fu, Ivan Sherstnev, Veronika Boichenko, Jiayue Ling, Madihah Hussain, Alina Zorn, Yuan Yan Sin, Houcheng Wang, Ao Li, Sasha Korogodski, Eduardo Torres, David Stirling, Kyle Chan, , Julia Gorelik
This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.
bioRxiv · Nov 2, 2026 · PreprintPharmacology & Toxicology