Genomic and proteomic evidence for hormonal and metabolic foundations of polycystic ovary syndrome
Loes M E Moolhuijsen, Jia Zhu, Benjamin H. Mullin, Natàlia Pujol‐Gualdo, Ky’Era V. Actkins, Jasmine A. Mack, Hridya Rao, Bhavi Trivedi, Katherine A. Kentistou, Yajie Zhao, David Westergard, Jaakko S. Tyrmi, Guðmar Þorleifsson, Yanfei Zhang, Laura B. L. Wittemans, , Felix R. Day
This study identifies 31 plasma proteins and expands genetic loci associated with PCOS, highlighting metabolic and hormonal influences and polygenic risk effects on cardio-metabolic outcomes.
medRxiv · Apr 18, 2024 · PreprintGenetic & Genomic Medicine