Metatranscriptomics reveals diverse microbial communities in PCR-negative severe acute respiratory infections
Nicola S Holdsworth, Rebecca K. French, Stephanie J. Waller, Lauren Jelley, Meaghan P O’Neill, Isa de Vries, Jeremy Dubrelle, Nigel French, Max Bloomfield, David Winter, Q. Sue Huang, Jemma L. Geoghegan
The paper uses metatranscriptomics to analyze PCR-negative SARI samples, identifying microbial transcripts in 43% of cases and highlighting polymicrobial compositions and novel pathogens.
bioRxiv · Oct 6, 2026 · PreprintGenomics