A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases
Rachael M. Cox, Ophelia Papoulas, Shirlee Shril, Chanjae Lee, Tynan P. Gardner, Zoya T. Ansari, Anna M. Battenhouse, Muyoung Lee, Kevin Drew, Claire D. McWhite, David Yang, Janelle C. Leggere, Dannie Durand, Friedhelm Hildebrandt, John B. Wallingford, Edward M. Marcotte
The paper reconstructs the protein interactome of the Last Eukaryotic Common Ancestor and identifies new human gene-disease associations for bone density and congenital birth defects.
Cell Genomics · May 27, 2026Peer-reviewedEvolutionary Biology