Title: Cell-autonomous and non-cell-autonomous effects of TRIM72 on ALS disease progression
Xue Zhang, Ji He, Ning Song, Xipeng Li, Weizhe Wang, Yueting Hu, Qing Li, Yiqing Hu, Chunmu Yin, Peng Zhao, Xinyi Jiang, Xuejiao Piao, Dawei Meng, Hongmei Cheng, Zhaohui Chen, , Yichang Jia
This study identifies TRIM72's protective role in ALS through both cell-autonomous and non-cell-autonomous mechanisms, showing its therapeutic potential in animal models and human patients.
bioRxiv · Jan 9, 2025 · PreprintNeuroscience