Qing Li

Single-cell transcriptome-wide association analysis reveals epithelial cell-specific genetic susceptibility to colorectal cancer

The paper performs single-cell transcriptome-wide association analysis to identify cell-type-specific genetic susceptibility genes for colorectal cancer, finding 546 gene-cell-type associations and 347 candidate susceptibility genes.

Pharmacological and Transcriptomic Exploration of β2-Adrenergic Receptor-Gα15 Signaling in THP-1-Derived Macrophages

This study investigates β2AR signaling through Gs and G15 in macrophages, showing differential activation and effects on polarization and repair-related gene expression.

ACC1-Dependent De Novo Lipogenesis Sustains Hematopoietic Stem Cell Quiescence and Self-Renewal

This study shows that ACC1-dependent de novo fatty acid synthesis is essential for maintaining HSC quiescence and self-renewal, with its loss leading to impaired function and increased fatty acid oxidation.

TetraFuse: A Synergistic Four-Dimensional Dynamic Fusion Framework for Efficient and Robust Medical Image Classification

TetraFuse improves medical image classification by integrating four domains to balance accuracy and efficiency, achieving high performance with reduced computational demand.

Genome Assembly of the Green Revolution Wheat Cultivar Pavon 76 Establishes a Reference for CIMMYT-Derived Wheat

The paper assembles the genome of Pavon 76, a Green Revolution wheat cultivar, providing a chromosome-scale reference for CIMMYT-derived wheat and highlighting structural divergence from the standard reference genome.

A UNIVERSAL FRAMEWORK FOR DISENTANGLING SUBJECT-SPECIFIC SIGNATURES IN EEG SIGNALS

This paper introduces a neural framework to separate subject-specific features from transient brain states in EEG signals, showing improved accuracy in biometric recognition.

Comprehensive analysis of TEAD inhibition in meningioma identifies MEK and mTOR inhibition as effective combination therapies against resistant lines.

This study identifies TEAD inhibition as a therapeutic target in meningioma and shows that combining MEK and mTOR inhibition overcomes resistance in resistant lines.

Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment

This study shows Lamin A/C regulates DNA replication by controlling chromatin accessibility and PCNA recruitment, preventing excessive replication initiation and DNA damage.

Neural Arming Niche in Tumor-Draining Lymph Nodes Programs CD8⁺T Cell Cytotoxicity via GZMB Norepinephrinylation

The paper shows that sympathetic norepinephrine in tumor-draining lymph nodes modifies GZMB in CD8 T cells to enhance cytotoxicity and improve tumor control.

Visualizing single base RNA mutations in living cells through DNA nanostructure mediated amplification

The paper introduces a DNA nanostructure-based platform for single-base RNA mutation detection in living cells, demonstrating its ability to distinguish insulin mRNAs and detect KRASG12D mutations with high specificity.

Title: Cell-autonomous and non-cell-autonomous effects of TRIM72 on ALS disease progression

This study identifies TRIM72's protective role in ALS through both cell-autonomous and non-cell-autonomous mechanisms, showing its therapeutic potential in animal models and human patients.

Towards genuine three-dimensional diffusion imaging with physiological motion compensation

This paper introduces a 3D diffusion-weighted imaging sequence with motion compensation and evaluates its performance on healthy volunteers and patients with ischemic lesions.

Widespread natural variation of DNA methylation within angiosperms

This study compares DNA methylation patterns across 34 angiosperm species, revealing widespread variation in methylation patterns linked to evolutionary and life history traits.