B cells targeting parasites capture spatially linked antigens to secure T cell help
Xin Gao, Hayley A. McNamara, Jiwon Lee, Adrian F. Lo, Deepyan Chatterjee, Dominik Spensberger, Daniel Fernandez‐Ruiz, Kevin Walz, Ke Wang, Hannah G. Kelly, Kai G. Pohl, Patricia E. Carreira, Andrea Do, Le Xiong, Lynette Beattie, , Ian Andrew Cockburn
The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.
Science Immunology · Nov 7, 2025Peer-reviewedImmunology