Author

Denise Dunn

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Scott FloydiD· 4 shared Jen‐Tsan ChiiD· 3 shared Ssu-Yu CheniD· 2 shared Alexander A. MestreiD· 1 shared Andrew Thompson· 1 shared Anna L. Price· 1 shared C. Skyler CochraneiD· 1 shared Chao-Chieh Lin· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

Scott FloydORCID

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Author profile →

4 papers

Recent·Most cited

Identification of 4,5,6,7-Tetrabromo-1H-benzotriazole (TBB) as a Small Molecule MESH1 Inhibitor that Suppresses Ferroptosis

Alexander A. Mestre, Yunju Oh, Jianli Wu, Denise Dunn, Yasaman Setayeshpour, Ssu-Yu Chen, Chao‐Chieh Lin, C. Skyler Cochrane, Pyeonghwa Jeong, Gibeom Nam, Chloe Markey, Daniel Reker, Scott Floyd, Jiyong Hong, Pei Zhou, Jen‐Tsan Chi

This paper identifies TBB as a small molecule inhibitor of MESH1 that suppresses ferroptosis in vitro and reduces neuronal death in an Alzheimer's disease model.

bioRxiv · Feb 20, 2026 · PreprintBiochemistry

Investigating Rat-Brain Normal Tissue and Tumor FLASH Effects with a Novel Very High Energy Electron Beam

Tyler V. Kay, Anna L. Price, Markus Sprenger, Victoria J. P. Radosova, Andrew Thompson, Eric L. Martin, Denise Dunn, V. Popov, S.F. Mikhailov, Zachary J. Reitman, Y. Wu, Scott Floyd, Mark Oldham

This study investigates FLASH radiation effects on rat brain tissue and tumors using a novel high-energy electron beam, finding differential immune responses and microglial changes.

bioRxiv · Sep 5, 2025 · PreprintCancer Biology

Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation

Jimin Hu, Duc T. Huynh, Denise Dunn, Jianli Wu, Cindy Manriquez-Rodriguez, Qianyi E Zhang, Gabrielle A. Hirschkorn, Tetsuya Hirata, George R Georgiou, Samuel A. Myers, Scott Floyd, Jen‐Tsan Chi, Michael Boyce

This study shows that KLHL3 and WNK kinases are regulated by O-GlcNAcylation, affecting osmolarity control and ferroptosis, with implications for blood pressure and neuronal health.

Glycobiology · Aug 11, 2025Peer-reviewedCell Biology

Targeting the ferroptosis pathway: A novel compound, AZD1390, protects the brain after ischemic stroke

Han Kyu Lee, Chao-Chieh Lin, Denise Dunn, Yubin Chen, Ssu-Yu Chen, Douglas A. Marchuk, Scott Floyd, Jen‐Tsan Chi

This study shows that ATM inhibition with AZD1390 reduces ferroptosis and neuronal death in ischemic stroke models.

bioRxiv · Feb 22, 2025 · PreprintNeuroscience