Tirzepatide preserves hematopoietic stem and progenitor cycling while remodeling inflammatory monocytes in obese mice
Nathan M. Krah, Elena González‐Alvarado, Amog P. Urs, Chinmayee Goda, Yaphet Bustos, James E. Marvin, Bradley D. Weaver, Spencer Gygi, Ashish Ganeshlalji Toshniwal, Dennis Towne, Álvaro Jesús Narbona‐Pérez, Katarina E. Heyden, Juan A. Cantres-Velez, Corey Nathaniel Cunningham, Sankalp Arora, , Amandine Chaix
This study compares the effects of tirzepatide and caloric restriction on hematopoiesis in obese mice, finding tirzepatide preserves HSPC cycling and reduces inflammatory monocytes while CR causes cytopenias.
bioRxiv · Sep 4, 2026 · PreprintImmunology