A blueprint for mutation-defined hallmark vulnerabilities across human cancers
Ran Xu, Rebecca San Gil, Xin Tracy Liu, Yanfei Qi, Derek Tran, Chun Xu, Justin J. -L. Wong, Lenka Munoz, Graham J. Mann, Yuchen Feng
This paper maps mutation-defined cancer vulnerabilities across 22 cohorts, identifying OXPHOS addiction in CDKN2A-loss LUSC and highlighting drug repurposing opportunities using a machine learning framework.
bioRxiv · Oct 24, 2025 · PreprintCancer Biology