Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma
George L. Joun, Emma G. Kempe, Brianna Chen, Jayden Sterling, Ramzi H. Abbassi, Dana Friess, Matthew Singleton, Chandra Choudhury, Oana C. Marian, Willem Daniel du Preez, Ariadna Recasens, Teleri Clark, Tian Y. Du, Jason K. K. Low, Hani Kim, , Lenka Munoz
This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.
Nature Communications · Dec 15, 2025Peer-reviewedCancer Biology