Systemic degradation of repressive transcription factors gates gene expression and cell fate specification
Predrag Jevtić, Samuel R Witus, Devlon M. McCloud, Zhi Yang, Ana Milunovic-Jevtic, Heegwang Roh, Michael Rapé
The paper shows proteasomes degrade repressive transcription factors, freeing chromatin for activator binding and enabling gene expression and cell fate decisions.
bioRxiv · Jun 18, 2026 · PreprintBiochemistry