Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex
David C. Williams, Jie Ren, Torry Li, Jarrett M. Pelton, Dhanushi Dedakia, Robert K. McGinty, Gordon D. Ginder, Albert A. Bowers
The paper identifies macrocyclic peptides that disrupt the CHD4-GATAD2A interaction in NuRD, revealing CHD4's role as an interaction hub and suggesting a therapeutic strategy for beta-hemoglobinopathies.
bioRxiv · Jun 7, 2026 · PreprintBiophysics