Reversal of the renal hyperglycemic memory by targeting sustained tubular p21 expression
Moh’d Mohanad Al‐Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian M Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Sumra Nazir, Ronny Baber, Markus R. Scholz, Robert Geffers, , Berend Heinrich Isermann
The paper identifies p21 as a key mediator of hyperglycemic memory in diabetic kidney disease and shows that aPC signaling can reverse its effects.
bioRxiv · Jul 5, 2021 · PreprintMolecular Biology