Detergent-Free Nuclear-Cytoplasmic Fractionation Enables Spatially Resolved PELSA for Enhanced Nuclear Drug Target Identification
Danni Cai, Kun Zou, Jiayi Wang, Haiyang Zhu, Yanni Ma, Jiayang Yan, Dian Yang, Xiaolei Zhang, Lijuan Zou, Keyun Wang, Mingliang Ye
This paper introduces a detergent-free nuclear-cytoplasmic fractionation method combined with PELSA to enhance detection of nuclear drug targets, showing improved identification of canonical and novel targets.
bioRxiv · Apr 13, 2026 · PreprintBiochemistry