Mingliang Ye

AutoPELSA automates the PELSA workflow for proteome-wide ligand-protein interaction detection, enabling high-throughput analysis of both strong and low-affinity ligands.

This study identifies Foxp2+ neurons in the medial preoptic area as a controllable node for inducing therapeutic hypothermia and demonstrates their antitumor effects.

This paper introduces a detergent-free nuclear-cytoplasmic fractionation method combined with PELSA to enhance detection of nuclear drug targets, showing improved identification of canonical and novel targets.

PELSA-Decipher processes and interprets PELSA data to extract ligand-protein interaction details like binding proteins, sites, and affinities.

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.