Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)
Wei Lin, Kalyan Das, David Degen, Abhishek Mazumder, Diego Duchi, Dongye Wang, Yon W. Ebright, Richard H. Ebright, Elena V. Sineva, Matthew Gigliotti, Aashish Srivastava, Sukhendu Mandal, Yi Jiang, Yu Liu, Ruiheng Yin, , Achillefs N. Kapanidis
This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.
Molecular Cell · Mar 29, 2018Peer-reviewedMolecular Biology