Author

Yi Jiang

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Molecular Biology· 2 Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

David DegeniD· 2 shared Kalyan DasiD· 2 shared Matthew Gigliotti· 2 shared Richard H. EbrightiD· 2 shared Sukhendu MandaliD· 2 shared Wei LiniD· 2 shared Yon W. EbrightiD· 2 shared Aashish SrivastavaiD· 1 shared

Activity by Year

2017-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

David DegenORCID

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5 papers

Recent·Most cited

A generalized life-motion mechanism supports invariant directional coding of local biological kinematics in humans

Zhihan Gao, Lianzi Xing, Rui Wang, Yi Jiang

The paper investigates how the human visual system encodes directional information from biological motion across species and actions, finding a generalized, direction-sensitive neural mechanism.

bioRxiv · Mar 16, 2026 · PreprintNeuroscience

Molecular Glue-Induced Homodimerization Drives Targeted CRBN Autodegradation

Lu Chen, Xiaoxiao Zou, Jiayin Liang, Jun Wang, Xiaolin Luo, Taiting Shi, Xinzhu Li, Shuke Yang, Linhui Cao, Yingjie Sun, Yue Zhao, Hewei Jiang, Yi Jiang, Zhipeng Su, Huan Xiong, , Wenchao Lu

This paper introduces LJY-3-60, a molecular glue that induces CRBN homodimerization and autodegradation, providing a tool for controlled protein degradation.

bioRxiv · Mar 10, 2026 · PreprintBiochemistry

How Visual Experience Shapes Face Processing: Divergent Representational Strategies Emerge from Specialized and Diverse Visual Diets in Artificial Neural Networks

Xiqian Lu, Yi Jiang

This study trains two ANNs on different visual diets to show how specialized vs. broad experience shapes face-processing capabilities and generalization.

bioRxiv · Feb 3, 2026 · PreprintNeuroscience

Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)

Wei Lin, Kalyan Das, David Degen, Abhishek Mazumder, Diego Duchi, Dongye Wang, Yon W. Ebright, Richard H. Ebright, Elena V. Sineva, Matthew Gigliotti, Aashish Srivastava, Sukhendu Mandal, Yi Jiang, Yu Liu, Ruiheng Yin, , Achillefs N. Kapanidis

This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.

Molecular Cell · Mar 29, 2018Peer-reviewedMolecular Biology

Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

Wei Lin, Soma Mandal, David Degen, Yu Liu, Yon W. Ebright, Shengjian Li, Yu Feng, Yu Zhang, Sukhendu Mandal, Yi Jiang, Shuang Liu, Matthew Gigliotti, Meliza T. Talaue, Nancy D Connell, Kalyan Das, , Richard H. Ebright

This study reports crystal structures of Mycobacterium tuberculosis RNA polymerase with and without antituberculosis drugs, revealing a new class of inhibitors and their binding mechanisms.

Molecular Cell · Apr 1, 2017Peer-reviewedMolecular Biology