Epigenetic Remodeling Increases Plasticity of Bovine Fibroblasts Without Improving Embryo and Stem Cell Development
Dewison Ricardo Ambrizi, Diego Moreno, Juliano Rodrigues Sangalli, Ricardo Perecin Nociti, Jessica B Cruz, Lais V F Pessoa, David Kendall, Fabiana Fernandes Bressan, Marcos Roberto Chiaratti, Lawrence Charles Smith, Pablo J. Ross, Flávio Vieira Meirelles, Rafael Vieira Sampaio
This study evaluates a multi-target small-molecule cocktail, GUSTC, to reduce repressive heterochromatin marks in bovine fibroblasts, enhancing reprogramming potential without improving embryo development.
bioRxiv · Oct 30, 2026 · PreprintDevelopmental Biology