Pablo J. Ross

This study evaluates a multi-target small-molecule cocktail, GUSTC, to reduce repressive heterochromatin marks in bovine fibroblasts, enhancing reprogramming potential without improving embryo development.

The paper constructs a bovine epigenomic atlas to annotate regulatory elements and decode the regulatory syntax of the cattle genome, aiding in fine-mapping GWAS loci for complex traits.

This study generates SOCS2 knock-out sheep using CRISPR-Cas9 ribonucleoprotein electroporation, resulting in compound heterozygotes with large deletions and trace SOCS2 expression.

The paper identifies an expanded subventricular zone in neonatal gyrencephalic brains that supports ongoing neuronal migration to the cortex.

The paper improves bovine genome annotation by integrating multi-omics data to identify novel transcripts and gene functions, and constructs a trait similarity network.

The paper uses Oxford Nanopore long-read sequencing to annotate transcript isoforms in 19 chicken tissues, identifying novel transcripts and highlighting tissue-specific expression patterns.

The paper investigates the effects of beta-hydroxybutyrate on histone lysine beta-hydroxybutyrylation and transcriptome changes in bovine fibroblasts and cumulus-oocyte complexes, showing altered gene expression but no impact on oocyte meiotic competence.

This study profiles histone modifications during bovine preimplantation development, showing their role in gene regulation and lineage specification.

This study maps transcription initiation sites in 31 bovine tissues, revealing promoter activity, pervasive transcription, and tissue-specific promoter usage comparable to human and mouse.

This study shows that porcine embryonic medial ganglionic eminence progenitors develop into interneurons similar to rodents, supporting their use in xenotransplantation therapies.

The paper identifies and compares chromatin accessibility in cattle, pig, and mouse tissues using ATAC-seq, finding species-specific regulatory elements and conservation patterns.

The paper profiles accessible chromatin in bovine embryos to show species-specific regulation of genome activation, finding similarities between cattle and humans but differences from mice.

This study uses CRISPR-based epigenetic editing to activate pancreatic beta-cell genes in human cells, showing that sequential activation of transcription factors is more effective than simultaneous activation.

This study inhibits EHMT1/2 with UNC0638 in bovine cells during reprogramming, reducing H3K9me2 and other marks but not improving preimplantation development.

This study investigates pig pancreatic islet development, identifying similarities with human islet ontogeny and uncovering signaling pathways relevant to beta-cell maturation.