A reversible GNAS-PKA-RUNX2 checkpoint governs skeletal stem cell fate in fibrous dysplasia
Sofía Cárdenas, Diego Rodriguez, Angelyn Solis, Kuniaki Sato, Tomohiko Ishikawa, Sendi Rafael Adame-Garcia, Tsubasa Ochiai, Johannes Köckenberger, Soo Hyun Shin, Jiang Du, Fleur Ferguson, Jorge Silvio Gutkind
This study identifies a reversible GNAS-PKA-RUNX2 checkpoint that governs skeletal stem cell fate in fibrous dysplasia and shows PKA inhibition can reverse disease features.
bioRxiv · Oct 6, 2026 · PreprintCell Biology