Author

Sendi Rafael Adame-Garcia

University of California San DiegoORCID 0000-0002-5665-8333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jorge Silvio GutkindiD· 3 shared Kuniaki SatoiD· 2 shared Angelyn Solis· 1 shared Chun-Liang CheniD· 1 shared Dana J. RammsiD· 1 shared Danielle L. SwaneyiD· 1 shared Diego Rodriguez· 1 shared Erica J. StevensoniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

Jorge Silvio GutkindORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 6, 2026

A reversible GNAS-PKA-RUNX2 checkpoint governs skeletal stem cell fate in fibrous dysplasia

Sofía Cárdenas, Diego Rodriguez, Angelyn Solis…·Jorge Silvio Gutkind

This study identifies a reversible GNAS-PKA-RUNX2 checkpoint that governs skeletal stem cell fate in fibrous dysplasia and shows PKA inhibition can reverse disease features.

DOI 10.64898/2026.10.02.756293

humanbulk RNA-seq

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Cell BiologybioRxivPreprintApr 6, 2026

The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation.

Pham Thuy Tien Vo, Julien Cicero, Zichen Wang…·Jorge Silvio Gutkind

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

DOI 10.64898/2026.04.03.716411

humanproteomics

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BiochemistryeLifePeer-reviewedDec 20, 2023

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

Sandeep Kaur Ravala, Sendi Rafael Adame-Garcia, Sheng Li…·John J. G. Tesmer

This study identifies structural changes in P-Rex1 upon activation by PIP3 and inhibition by IP4, revealing how these interactions regulate its GEF activity.

9 citations

structural biologyexperimental assay

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