Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity
Christian B. Lessard, Diego Rubio-Rubio, Samantha G Tolton, Marangelie Criado‐Marrero, Sakthivel Ravi, Tristyn N. Garza, John Koren, Jennifer Phillips, Pritha Bagchi, Karen N. McFarland, Deepak Chhangani, Todd Eliot Golde, Benoit I. Giasson, Jada M. Lewis, Paramita Chakrabarty, , Jose Francisco Abisambra
This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.
bioRxiv · Jun 30, 2025 · PreprintNeuroscience