Molecular BiologybioRxivPreprint
Molecular dissection of pro-fibrotic signaling identifies the mechanism underlying IL11-driven fibrosis gene translation, reveals non-specific effects of STAT3 and suggests a new mechanism of action for nintedanib
Anissa Anindya Widjaja, Sivakumar Viswanathan, Dong Jinrui…·Stuart A. Cook
The paper investigates IL11-driven fibrosis mechanisms, showing ERK, not STAT3, drives fibrogenesis and identifies a novel role for nintedanib in inhibiting pro-fibrotic translation.
DOI 10.1101/2021.06.10.447846