A reporter mouse model to map RIG-I expression and function in vivo
Stephen A Ehrenzeller, Amy C Hinesley, Sergio Borunda, Suhan Liu, Daniel O Richards, Dong-il Kwon, Timothy M Mehrmann, William M Phillbrick, Daniel T Thoresen, Richard A Flavell, Anna Marie Pyle, Akiko Iwasaki
This paper develops a RIG-I reporter mouse model to track RIG-I expression and function in vivo, revealing its tissue distribution and identifying alveolar macrophages as key sensor cells.
bioRxiv · Nov 6, 2026 · PreprintImmunology