Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice.
Donita L. Garland, Eric A. Pierce, Rosario Fernández‐Godino
This study shows that C5 ablation does not prevent sub-RPE deposit formation in Efemp1 mutant mice, suggesting C3, not C5, may be a better therapeutic target for early AMD.
Scientific Reports · May 17, 2021Peer-reviewedNeuroscience