A COJEC-chemotherapy resistant model of Th-ALK(F1174L)/MYCN neuroblastoma offers insights into tumour immune evasion and development of the bone marrow metastatic niche
Elizabeth R. Tucker, Andrea Lampis, Jacob Househam, Duncan Roberts, Karen T. Barker, Barbara Martins Da Costa, Kevin Greenslade, Sarah Mayfield, Federica Lorenzi, Emma Thorley, Vidur Tandon, Nan Sophia Han, Giulia Emanuelli, Marwane Bourdim, Georgia Martin, , Louis Chesler
This study develops a neuroblastoma mouse model to investigate chemotherapy resistance and immune evasion mechanisms, identifying CDK8 upregulation and immune cell infiltration as key factors.
bioRxiv · Sep 2, 2026 · PreprintCancer Biology