Protein expression is amplified by stabilizing mRNA using gene-specific antisense oligonucleotides
Benjamin D. Boros, Aishwarya Nambiar, Miwei Hu, Dylan A. Galloway, Colin P. Florian, Courtney F. Jungers, Joseph D. Dougherty, Kathleen M. Schoch, Sergej Djuranović, Timothy M. Miller
The paper demonstrates that antisense oligonucleotides (ASOs) can upregulate gene expression by stabilizing mRNA through targeting destabilizing elements like PREs, with therapeutic implications for haploinsufficiency disorders.
bioRxiv · Sep 17, 2026 · PreprintMolecular Biology