Comprehensive analysis of TEAD inhibition in meningioma identifies MEK and mTOR inhibition as effective combination therapies against resistant lines.
Dylan J Keiser, Meghan S Buddy, Solmaz Mojarad-Jabali, Qing Li, Missia Kohler-Skinner, Abigail G Parrish, David L. Gillespie, David Austin Nix, Sheri L. Holmen, Howard Colman, William Couldwell, Randy L. Jensen, Frank Szulzewsky
This study identifies TEAD inhibition as a therapeutic target in meningioma and shows that combining MEK and mTOR inhibition overcomes resistance in resistant lines.
bioRxiv · Mar 25, 2026 · PreprintCancer Biology