Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB
E. A. King, Y. Cho, D. Dovala, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura
This study identifies a covalent molecular glue degrader, EN450, that induces the degradation of NFKB1 via a ternary complex with UBE2D, leading to anti-proliferative effects in leukemia cells.
bioRxiv · May 18, 2022Biochemistry