Y. Cho

The Hippo pathway effector YAP inhibits NF-kB signaling and ccRCC growth by opposing ZHX2

This study shows YAP inhibits NF-κB signaling and ccRCC growth by blocking ZHX2, a co-factor of NF-κB, and competes with ZHX2 for binding to p65.

Differential growth enhancement followed by notable microbiota modulation in growing-finishing pigs by Bacillus subtilis strains ps4060, ps4100, and a 50:50 strain mixture

This study evaluates the effects of Bacillus subtilis strains and their mixture on pig growth and gut microbiota, finding improved weight gain and microbiota modulation.

Intrinsic skeletal muscle function and contraction-stimulated glucose uptake do not vary by time-of-day in mice

This study shows that intrinsic skeletal muscle function and contraction-stimulated glucose uptake in mice do not vary across the 24-hour circadian cycle.

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under control of antigen sensing in microwell arrays

This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.

Alternative splicing variants of Arabidopsis G protein β subunit AGB1 function in plant development and endoplasmic reticulum stress response

This study identifies four alternative splice isoforms of AGB1 in Arabidopsis, showing they have distinct functions in plant development and ER stress response.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

A complex tissue-specific interplay between the Arabidopsis transcription factors AtMYB68, AtHB23, and AtPHL1 modulates primary and lateral root development and adaptation to salinity

Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.

This study shows that loss of obscurin and Obsl1 in mice causes diastolic dysfunction, altered metabolism, and deregulated mitophagy in the heart.

Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB

This study identifies a covalent molecular glue degrader, EN450, that induces the degradation of NFKB1 via a ternary complex with UBE2D, leading to anti-proliferative effects in leukemia cells.

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

Combination of an inject-and-transfer system for serial femtosecond crystallography

This paper introduces a new sample delivery method for serial femtosecond crystallography, enabling reliable crystal deposition and successful structure determination of lysozyme.

Lack of Age-related Respiratory Changes in Daphnia

The paper examines age-related changes in respiration rates, lactate/pyruvate ratio, and mitochondrial membrane potential in Daphnia magna, finding no significant age-related changes except for a possible peak in mitochondrial membrane potential in specific tissues.

"Smart Tanks": An Intelligent High-Throughput Intervention Testing Platform in Daphnia

The paper introduces a platform for high-throughput intervention testing in Daphnia magna, using machine learning to estimate phenotypic age under pharmacological perturbations.

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

Viscous medium-based crystal support in sample holder for fixed-target serial femtosecond crystallography

This paper introduces a viscous medium-based sample holder for fixed-target serial femtosecond crystallography, enabling stable crystal support for various sizes and shapes.

HeALTH: An Automated Platform for Long-term Longitudinal Studies of Whole Organisms under Precise Environmental Control

The paper introduces HeALTH, an automated microfluidic system for longitudinal behavioral studies of C. elegans under precise environmental control, demonstrating its utility in aging research and beyond.

High specificity of widely used phospho-tau antibodies validated using a quantitative whole-cell based assay

The paper validates the specificity of phospho-tau antibodies using a flow cytometry assay and finds that some antibodies show significant non-specific binding.

Instant Automated Inference of Perceived Mental Stress through Smartphone PPG and Thermal Imaging

This paper develops a smartphone-based system using PPG and thermal imaging to instantly detect mental stress within 20 seconds, achieving 76.96% accuracy using neural networks.