Various evolutionary trajectories lead to loss of the tobramycin-potentiating activity of the quorum sensing inhibitor baicalin hydrate in Burkholderia cenocepacia biofilms
A. Sass, L. Slachmuylders, H. Van Acker, I. Vandenbussche, L. Ostyn, A. Crabbe, L. Chiarelli, S. Buroni, F. Van Nieuwerburgh, E. Abatih, T. Coenye
This study shows that biofilms of Burkholderia cenocepacia develop resistance to the antibiotic-potentiating activity of baicalin hydrate through various genetic changes.
bioRxiv · Sep 6, 2018Microbiology