Cryo-sensitive aggregation triggers NLRP3 inflammasome assemblyin cryopyrin-associated periodic syndrome
T. Karasawa, T. Komada, N. Yamada, E. Aizawa, Y. Mizushina, S. Watanabe, C. Baatarjav, T. Matsumura, M. Takahashi
This study identifies cryo-sensitive NLRP3 aggregates as a scaffold for inflammasome activation in CAPS, showing Ca2+ influx is essential for this process.
eLife · May 26, 2022Peer-reviewedImmunology