M. Takahashi

The paper analyzes over 700 genomes of Corynebacterium ulcerans and C. ramonii isolates to reveal geographic differences in sequence types and toxigenic prophage compositions, with ST337 predominating in Japan and associations between prophage types and toxin production.

The paper analyzes the relationship between pigmentation level and gene expression in human iPSC-derived RPE cells, finding no specific gene expression profile correlates with color intensity.

The paper investigates gene flow between island and continental populations of Swinhoe's Rail, finding asymmetric gene flow from island to continental populations and a role for islands as genetic reservoirs.

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

This study identifies the genomic basis of female-limited morphs and male mimicry in damselflies, revealing structural variants and transposable element activity driving these phenotypes.

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

This study shows kaempferol suppresses mast cell activation by reducing FcεRI surface expression and increasing SHIP1 levels, independent of transcription and translation.

This study shows that LDL3-mediated H3K4me2 demethylation occurs cotranscriptionally in Arabidopsis, disrupting the negative correlation between H3K4me2 and transcription in the ldl3 mutant.

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

This study investigates the role of NNMT in regulating SAM and MNAM metabolism in AML12 hepatocytes, finding that NNMT is a significant consumer of SAM and critical for MNAM production.

This study identifies cryo-sensitive NLRP3 aggregates as a scaffold for inflammasome activation in CAPS, showing Ca2+ influx is essential for this process.

This paper introduces a novel system using sialic acid receptor-knockout cells to study influenza A virus receptor tropism, revealing unique biological tropism undetectable by conventional assays.

The paper identifies OsCBMIP, a rice protein that binds to fungal CBM1 domains in xylanases, inhibiting their activity and enhancing rice defense against M. oryzae.

The paper investigates how viral infection affects tRNA recycling by analyzing mRNA levels of tRNase ZS and TRNT1 in HeLa cells, finding upregulation in response to Theiler's mouse encephalitis virus but not influenza A virus.

This paper introduces a fluorescent probe, ECGreen, for live-cell imaging of endocytosis, showing increased fluorescence upon internalization into acidic vesicles.

This study converts pro-tumor CAFs to anti-tumor CAFs using Meflin induction, enhancing PDAC chemosensitivity through improved drug delivery and reduced tissue stiffness.

The paper isolates and characterizes a glucose homopolymer from broccoli with immunostimulatory effects in both arthropod and mammalian systems.

This paper introduces new fluorescent dyes for long-term and low-toxicity imaging of plasma membranes in neurons and exosomes.

This study shows that epithelial HVEM supports basement membrane synthesis and IET survival and migration in the intestine.

The paper develops CRISPR-Cas9 mutants of U87MG cells to create platform cell lines for drug testing, finding that transcriptomic analysis helps identify clones with minimal phenotypic divergence from wild type.

This study develops a simplified method to induce RPE-like cells from human fibroblasts and validates their properties using single-cell RNA sequencing.

The paper identifies structural destabilization and degradation of MLH1 variants in Lynch syndrome, linking reduced cellular levels to loss-of-function and suggesting stability predictions for diagnostic use.

Attenuated Salmonella typhimurium reduces tumor burden in mice by directly affecting the tumor epithelium through transcriptional and metabolic changes.

The paper identifies phosphoprotein biomarkers for Cdk5 activity in neuroendocrine tumors and shows their predictive value for anti-Cdk5 therapy.

This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.

This study generates ESC-derived CD105+ stromal cells with long-term proliferation and myogenic potential as a cell source for myoblast therapy in muscular disorders.