The immediate early protein 1 of human herpesvirus 6B counteracts ATM activation in an NBS1-dependent manner
V. Collin, E. Biquand, V. Tremblay, E. G. Lavoie, J. Dessapt, A. Blondeau, A. Gravel, L. Flamand, A. Fradet-Turcotte
This paper shows that HHV-6B IE1 inhibits ATM activation at double-strand breaks via NBS1 interaction, leading to genomic instability and affecting viral replication.
bioRxiv · Jul 31, 2021 · PreprintMicrobiology