A. Garcia-Sastre

Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

Enhanced mucosal B- and T-cell responses against SARS-CoV-2 after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant.

This study shows that combining intramuscular mRNA priming with intranasal protein boosting using a combination adjuvant enhances mucosal B- and T-cell responses against SARS-CoV-2 compared to other vaccination regimens.

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.

Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate AVX/COVID-12 Activates T Cells and Is Recognized by Antibodies from COVID-19 Patients and Vaccinated

This paper evaluates the AVX/COVID-12 vaccine's ability to activate T cells and bind antibodies from vaccinated individuals and SARS-CoV-2-infected patients.

Patient Subtyping Analysis of Baseline Multi-omic Data Reveals Distinct Pre-immune States Predictive of Vaccination Responses

The paper analyzes baseline multi-omic data from influenza vaccine recipients to identify pre-immune states predictive of vaccination responses.

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice.

This study evaluates how lipid nanoparticle (LNP) composition and adjuvant combinations affect immune responses and protection in mice vaccinated against influenza.

Protocol for primary human lung organoid-derived air-liquid interface in vitro model to study response to SARS-CoV-2

This paper presents a protocol for creating human lung organoid-derived air-liquid interface cultures to study SARS-CoV-2 infection and includes quality control and monitoring methods.

Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection

This study shows that heterologous immunization primes antigen-specific memory CD4 T cells, enhancing early germinal center response but not antibody generation in influenza infection.

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia

This study examines the spatiotemporal immune response to SARS-CoV-2 in human broncho-alveolar epithelia, finding variant-specific kinetics and spatially organized gene expression patterns.

Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants.

This study develops a measles-based vaccine encoding SARS-CoV-2 spike glycoproteins that enhances neutralizing antibody responses against both omicron and historical variants.

Visualization of early RNA replication kinetics of SARS-CoV-2 by using single molecule RNA-FISH

This study uses smRNA-FISH to visualize SARS-CoV-2 gRNA and sgRNA replication kinetics, revealing asynchronous replication and RO formation within 2 hours post-infection.

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity

This paper identifies a small molecule RIG-I agonist, KIN1148, that enhances influenza vaccine immunity by activating non-canonical RIG-I pathways to boost both antibody and T cell responses.

Antigenic landscape analysis of individuals vaccinated with a universal influenza virus vaccine candidate reveals induction of cross-subtype immunity

The paper analyzes immune responses to a universal influenza vaccine using a microarray to show broad antibody coverage against group 1 hemagglutinins.

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

The paper identifies novel non-covalent and covalent inhibitors of SARS-CoV-2 main protease through virtual docking and experimental validation.

Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice

The paper tests a trivalent NDV-HXP-S vaccine against SARS-CoV-2 variants in mice, showing increased protection and cross-neutralizing antibodies against Omicron.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

This study evaluates the antiviral activity of nirmatrelvir, molnupiravir, and remdesivir against the SARS-CoV-2 Omicron variant and confirms their potency.

Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection

This study shows that type I IFN promotes the maturation of inflammatory monocytes into pathogenic FasL+MCs during H5N1 infection, contributing to disease severity.

A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccine

This paper shows that a single amino acid change in the PB1 protein of the pandemic H1N1 virus can create a live-attenuated vaccine with reduced pathogenicity and transmission.

Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing

This study evaluates scRNA-Seq methods for detecting SARS-CoV-2 subgenomic mRNAs, finding that 10X 5' with extended R1 sequencing best captures these viral RNAs at single-cell resolution.

Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant

This study investigates sheep susceptibility to SARS-CoV-2 and finds that they show low susceptibility, with the alpha variant outcompeting the ancestral lineage.

Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer

This study shows adult white-tailed deer are susceptible to SARS-CoV-2 and can transmit it vertically and horizontally, with the alpha variant outcompeting the ancestral strain.

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine.

This study shows that a live attenuated influenza virus vaccine lacking NS1 provides broad protection against respiratory viruses including SARS-CoV-2 by inducing both innate and adaptive immune responses.

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

The virucidal effects of 405 nm visible light on SARS-CoV-2 and influenza A virus

This study shows that 405 nm visible light can inactivate SARS-CoV-2 and influenza A virus without porphyrins, using safe irradiance levels, suggesting potential for decontamination in occupied spaces.