E. Bosis

A T6SS in the coral pathogen Vibrio coralliilyticus secretes an arsenal of anti-eukaryotic effectors and contributes to virulence

This study identifies two temperature-regulated T6SSs in Vibrio coralliilyticus, revealing their roles in bacterial competition and host toxicity, with T6SS2 secreting nine novel anti-eukaryotic toxins.

An N-terminal delivery domain defines a new class of polymorphic T6SS effectors in Enterobacterales

The paper identifies a new N-terminal PIX domain in T6SS effectors from Pantoea agglomerans, showing it is essential for secretion and binds to a specialized VgrG protein.

Gamma-Mobile-Trio systems define a new class of mobile elements rich in bacterial defensive and offensive tools

The paper identifies GMT-containing genomic islands as mobile elements that carry both anti-phage defense systems and antibacterial offensive tools, highlighting their role in bacterial survival and dissemination.

Vibrio parahaemolyticus T6SS2 effector repertoires

This study identifies the T6SS2 effector repertoire in Vibrio parahaemolyticus using proteomics, revealing core and accessory effectors and a quality control checkpoint.

A new class of polymorphic T6SS effectors and tethers

The paper identifies RIX as a new domain defining polymorphic T6SS effectors and tethers, expanding the known repertoire of T6SS cargo and suggesting a broader role in vibrio-eukaryote interactions.

Multiple T6SSs, mobile auxiliary modules, and effectors revealed in a systematic analysis of the Vibrio parahaemolyticus pan-genome

The paper systematically analyzes the T6SS gene clusters and auxiliary modules in the Vibrio parahaemolyticus pan-genome, identifying diverse T6SS systems and novel effectors.

A DNase T6SS effector requires its MIX domain for secretion

The paper identifies a DNase toxin domain in a Vibrio parahaemolyticus T6SS effector and shows its necessity for secretion and toxicity.

A binary effector module secreted by a type VI secretion system

The paper identifies a new T6SS secretion mechanism where an effector and co-effector are secreted together, termed a binary effector module, found in marine bacteria.

Formylglycine-generating enzyme-like proteins constitute a novel family of widespread type VI secretion system immunity proteins

This study identifies Tsi3 as a T6SS immunity protein with an FGE domain, showing it prevents self-intoxication by interacting with Tse3 but is not a functional enzyme.