Author

E. Calkins

Portland VA Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

AeSoon L. BenseniD· 1 shared B. A. Napier· 1 shared B. Emery· 1 shared Ben EmeryiD· 1 shared D. Bourdette· 1 shared DENNIS N. BOURDETTEiD· 1 shared E. Pocius· 1 shared Edvinas PociusiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

AeSoon L. BensenORCID

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2 papers

Recent·Most cited

TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor

S. J. Ferrara, P. Chaudhary, M. J. DeBell, G. Marracci, H. Miller, E. Calkins, E. Pocius, B. A. Napier, B. Emery, D. Bourdette, T. S. Scanlan

This study shows TREM2 is regulated by thyroid hormone and demonstrates that thyroid hormone agonists can modulate TREM2 pathway activity in myeloid cells, offering a potential therapeutic strategy for diseases involving TREM2.

bioRxiv · Jan 25, 2021Immunology

Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE

Priya Chaudhary, Gail Marracci, E. Calkins, Edvinas Pocius, AeSoon L. Bensen, Thomas S. Scanlan, Ben Emery, DENNIS N. BOURDETTE

This study shows that thyroid hormone and thyromimetics reduce disease severity and protect oligodendrocytes in EAE by decreasing myelin and axonal degeneration.

Journal of Neuroimmunology · Dec 27, 2020Peer-reviewedNeuroscience