Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification
S. L. van der Beek, A. Zorzoli, E. Canak, R. N. Chapman, B. H. Meyer, G.-J. P. H. Boons, H. C. Dorfmueller, N. M. van Sorge
This study functionally characterizes dTDP-L-rhamnose biosynthesis enzymes in Streptococcus pyogenes and identifies Ri03 as a lead compound inhibiting growth of GAS and related pathogens.
bioRxiv · Jun 22, 2018Microbiology