Recombinant Group A Carbohydrate backbone embedded into Outer Membrane Vesicles is a potent vaccine candidate targeting Group A Streptococcus from Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis
S. Ajay Castro, S. Thomson, A. Zorzoli, B. H. Meyer, M. Reglinski, H. C. Dorfmueller
This study demonstrates that recombinant polyrhamnose (pRha) embedded in outer membrane vesicles (OMVs) induces potent antibodies against Group A Streptococcus, effectively killing hypervirulent strains.
bioRxiv · Nov 12, 2021 · PreprintMicrobiology